Acetyl-CoA Carboxylase (ACC)
ACC is a critical
enzyme that controls the synthesis and burning of fat. Inhibition of ACC with small molecule
agents could effectively mimic exercise creating new options to treat obesity, diabetes
and complications of metabolic syndrome.
In addition, recent studies have shown that ACC function is required for
tumorigenesis, especially in breast cancer and ACC has become an emerging target in cancer
metabolism
ACC has been very hard to drug effectively. By targeting a unique allosteric domain, the Nimbus approach has led to drug-like compounds with substantially improved potency versus traditional chemistries.
Download the poster presented by Nimbus Discovery at the 2013 Keystone Meeting:
