ACC is a critical enzyme that controls the synthesis and burning of fat. Inhibition of ACC with small molecule agents could effectively mimic exercise creating new options to treat obesity, diabetes and complications of metabolic syndrome. In addition, recent studies have shown that ACC function is required for tumorigenesis, especially in breast cancer and ACC has become an emerging target in cancer metabolism
ACC has been very hard to drug effectively. By targeting a unique allosteric domain, the Nimbus approach has led to drug-like compounds with substantially improved potency versus traditional chemistries.